Despite intensive efforts to stem the spread of malaria across Southeast Asia, concerns are rising that new strains of the malady are resistant to the drugs developed to fight it. “The emergence of resistance… threatens worldwide malaria control and treatment since there is no alternative to this drug if its efficacy decreases further and the resistance spreads outside the region,” according to the Global Fund to Fight AIDS, Tuberculosis and Malaria, which is providing US$150 million for malaria prevention and elimination programs in the Greater Mekong sub-region within the next two years.